Cafe Trend&Trade - III

**WYATT EARP** · 16-04-2020, 12:58

Hindistan ve benzeri ulkelerde eskiden sitma buyuk problemdi...kinin ile bu problemi cozduler...kinin'in yarattigi bagisiklik corona'ya karsi etkili olmus olabilir...
Boyle bir dusunce var....
Dogru olabilir mantikli gozukuyor

Originally Posted by kxsr

Hindistan, pakistan, sri lanka gibi iç içe yaşayan ülkeler neden endişe kaynağı değil acaba?

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**kxsr** · 16-04-2020, 13:03

Originally Posted by WYATT EARP

Hindistan ve benzeri ulkelerde eskiden sitma buyuk problemdi...kinin ile bu problemi cozduler...kinin'in yarattigi bagisiklik corona'ya karsi etkili olmus olabilir...
Boyle bir dusunce var....
Dogru olabilir mantikli gozukuyor

SM-A505F cihazımdan hisse.net mobile app kullanarak gönderildi.

umarım bu düşünce çıkar yoksa yıkıcı olabilir.

**WYATT EARP** · 16-04-2020, 13:05

Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries.*For decades, the drug was a front-line treatment and prophylactic for malaria.

Editor's note: Do not take any form of chloroquine or hydroxychloroquine without medical supervision.

In a three-page paper published Tuesday in*Cell Research,scientists at the Wuhan Institute of Virology’s State Key Laboratory of Virology write that both chloroquine and the antiviral remdesivir were, individually, “highly effective” at inhibiting replication of the novel coronavirus in cell culture. Their drug screen evaluated five other drugs that were not effective. The authors could not be reached for comment.

[https://www]

YINAN CHEN/GOOD FREE PHOTOS

Chloroquine prescription bottle and tablet.

Though the paper is brief,*John Lednicky, a professor at the University of Florida’s Emerging Pathogens Institute, found its results intriguing. “It’s interesting in that it really lacks a lot of details but, nevertheless, if you look at the data as presented, at least in vitro, it seems like chloroquine can be used as an early-stage drug,” he said. “It would be very good if these types of experiments were repeated by more laboratories to see whether the same results occur across the board.”
Chloroquine is a synthetic form of quinine, a compound found in the bark of cinchona trees native to Peru and used for centuries to treat malaria. Chloroquine was an essential element of mass drug administration campaigns to combat malaria throughout the second half of the 20th century, and remains one of the World Health Organization’s*essential medicines. However, after the malaria parasites Plasmodium falciparum and Plasmodium vivax began exhibiting resistance to the drug in the 1960s and 1980s, respectively, it was replaced by similar antimalarial compounds and combination therapies. Chloroquine is still widely used against the three other species of plasmodium and to treat autoimmune disorders and some cases of amebiasis, an intestinal infection caused by the amoeba Entamoeba histolytica.
Chloroquine’s antiviral properties were explored in the mid-1990s against HIV and in the following decade against severe acute respiratory syndrome, or SARS, which is*closely related*to the novel coronavirus. In*2004, researchers in Belgium found that chloroquine inhibited replication of SARS in cell culture. The following year, however, another team at Utah State University and the Chinese University of Hong Kong evaluated a gamut of compounds against SARS replication in mice infected with the virus,*finding that*chloroquine was only effective as an anti-inflammatory agent. They recommended that it could be used in combination with compounds that prevent replication. Nevertheless,*in 2009,*the Belgian group found that lethal infections of human coronavirus OC43, a relative of SARS, could be averted in newborn mice by administering chloroquine through the mother’s milk.
Chloroquine raises the pH in host-cell lysosomes, which interferes with viruses’ attempts to acidify the lysosomes, a prerequisite to formation of the*autophagosomes*that cells use to eat themselves. In the Cell Research paper, the researchers found that the drug was effective at inhibiting the virus as it was both entering and exiting cells.
Craig Cameron*is a virologist at the University of North at Chapel Hill. “There is mounting evidence that many viruses hijack this cellular autophagy pathway for the good of the virus, but it is not completely clear why,” he said.
The second compound, remdesivir, is a nucleoside analog*discovered in 2016*that inhibits viral polymerase activity, shutting down transcription and synthesis of viral RNA. This gives it antiviral activity against a broad range of retroviruses, including Ebola (for which the drugmaker Gilead developed and tested it, unsuccessfully,*during*the 2018-2020 epidemic in the Democratic Republic of the Congo) and*coronaviruses.

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**DeliKAN** · 16-04-2020, 13:06

Originally Posted by kxsr

Hindistan, pakistan, sri lanka gibi iç içe yaşayan ülkeler neden endişe kaynağı değil acaba?

Belki de aşırı ve çok çeşitli baharat kullanımı yüzündendir.

**british** · 16-04-2020, 13:47

Turan Akıncı Yazıları

PANDEMİ İŞLERİ
Bu yaşadığımız salgın insanların düzenleri bozdu.
Ekonomik düzeni bozulanlar da çaresiz.
Bu salgın işleri yeni değil.
Osmanlı’nın son dönemlerinde 25 yılda bir salgın olurdu.
O dönemin salgını veba hastalığıydı.
Bu hastalığa KARA ÖLÜM denirdi.
Hatta karantina bir sefer altı yıl sürmüştü.
1839 yılında Karantina bakanlığı kurulmuştu.
++

Sultan II. Mahmut döneminde uzun süreli bir veba salgını oldu.
Camilerde günlerce dualar okundu,
Tabii hiçbir işe yaramadı.
O dönemin halkları kurtuluşu dua da görürdü.
Salgının sonlarına doğru,
Ermeni kilisesi mensupları haç çıkarıp günlerce,
Sokaklarda yürüdüler ve ilahiler söylediler.
O dönemde veba salgının sonuna gelinmişti.
Sultan II. Mahmut Surp Pirgiç kilisesinin
Yaptığı duaların bir şeye yaradığına inanmıştı.
++

Sultan II. Mahmut salgın sona erince,
Surp Pirgiç kilisesine hatırı sayılır bir mücevher hediye etti.
Bugün bu mücevher özenle saklanıyor.
Bugün kilisenin cemaati kalmadı.
Ama yanındaki sokağın müritleri,
İstanbul’un en büyük cemaati.